Title : Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma.

Pub. Date : 2015 Mar

PMID : 25179733






2 Functional Relationships(s)
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1 Functionally, inhibition of MARCKS phosphorylation by enzastaurin or knockdown of the gene by RNAi significantly enhanced the sensitivity of resistant HMCLs and primary MM samples to bortezomib and to other anti-myeloma drugs, providing evidence that MARCKS can modulate drug response. Bortezomib myristoylated alanine rich protein kinase C substrate Homo sapiens
2 Importantly, MARCKS knockdown in combination with bortezomib treatment overcame bortezomib resistance, significantly inhibited tumor growth and prolonged host survival in a MM xenograft model. Bortezomib myristoylated alanine rich protein kinase C substrate Homo sapiens