Pub. Date : 2014 May 26
PMID : 24796862
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol, a modulator of several signaling proteins, can exert off-target effects involving the peroxisome proliferator-activated receptor (PPAR) transcription factors. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | Resveratrol, a modulator of several signaling proteins, can exert off-target effects involving the peroxisome proliferator-activated receptor (PPAR) transcription factors. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | Here, we addressed the hypothesis that resveratrol and its metabolites control aspects of PPAR transcriptional activity through direct interaction with PPARs. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 4 | Bioaffinity chromatographic studies with the immobilized ligand-binding domains (LBDs) of PPARgamma and PPARalpha and isothermal titration calorimetry allowed the binding affinities of resveratrol, resveratrol 3-O-glucuronide, resveratrol 4-O-glucuronide, and resveratrol 3-O-sulfate to both PPAR-LBDs to be determined. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 5 | Bioaffinity chromatographic studies with the immobilized ligand-binding domains (LBDs) of PPARgamma and PPARalpha and isothermal titration calorimetry allowed the binding affinities of resveratrol, resveratrol 3-O-glucuronide, resveratrol 4-O-glucuronide, and resveratrol 3-O-sulfate to both PPAR-LBDs to be determined. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 6 | Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 7 | Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 8 | Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 9 | Transactivation assays were also performed in HepG2 cells, with the results showing that resveratrol was not a PPAR agonist but instead was able to displace rosiglitazone from PPARgamma and Wy-14643 from PPARalpha with IC50 values of (27.4+-1.8) muM and (31.7+-2.5) muM, respectively. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 10 | We propose that resveratrol acts as a PPAR antagonist through its direct interaction with PPARgamma and PPARalpha. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 11 | We propose that resveratrol acts as a PPAR antagonist through its direct interaction with PPARgamma and PPARalpha. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |