PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24796862-1	2014	Resveratrol, a modulator of several signaling proteins, can exert off-target effects involving the peroxisome proliferator-activated receptor (PPAR) transcription factors.	Resveratrol	0-11	peroxisome proliferator activated receptor alpha	Homo sapiens	99-141	
24796862-1	2014	Resveratrol, a modulator of several signaling proteins, can exert off-target effects involving the peroxisome proliferator-activated receptor (PPAR) transcription factors.	Resveratrol	0-11	peroxisome proliferator activated receptor alpha	Homo sapiens	143-147	
24796862-3	2014	Here, we addressed the hypothesis that resveratrol and its metabolites control aspects of PPAR transcriptional activity through direct interaction with PPARs.	Resveratrol	39-50	peroxisome proliferator activated receptor alpha	Homo sapiens	90-94	
24796862-4	2014	Bioaffinity chromatographic studies with the immobilized ligand-binding domains (LBDs) of PPARgamma and PPARalpha and isothermal titration calorimetry allowed the binding affinities of resveratrol, resveratrol 3-O-glucuronide, resveratrol 4-O-glucuronide, and resveratrol 3-O-sulfate to both PPAR-LBDs to be determined.	Resveratrol	185-196	peroxisome proliferator activated receptor alpha	Homo sapiens	104-113	
24796862-4	2014	Bioaffinity chromatographic studies with the immobilized ligand-binding domains (LBDs) of PPARgamma and PPARalpha and isothermal titration calorimetry allowed the binding affinities of resveratrol, resveratrol 3-O-glucuronide, resveratrol 4-O-glucuronide, and resveratrol 3-O-sulfate to both PPAR-LBDs to be determined.	Resveratrol	185-196	peroxisome proliferator activated receptor alpha	Homo sapiens	90-94	
24796862-5	2014	Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM.	Resveratrol	15-26	peroxisome proliferator activated receptor alpha	Homo sapiens	220-229	
24796862-5	2014	Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM.	Resveratrol	28-39	peroxisome proliferator activated receptor alpha	Homo sapiens	220-229	
24796862-5	2014	Interaction of resveratrol, resveratrol 3-O-glucuronide, and resveratrol 4-O-glucuronide with PPARgamma-LBD occurred with binding affinities of 1.4, 1.1, and 0.8 muM, respectively, although only resveratrol bound to the PPARalpha-LBD with a binding affinity of 2.7 muM.	Resveratrol	28-39	peroxisome proliferator activated receptor alpha	Homo sapiens	220-229	
24796862-8	2014	Transactivation assays were also performed in HepG2 cells, with the results showing that resveratrol was not a PPAR agonist but instead was able to displace rosiglitazone from PPARgamma and Wy-14643 from PPARalpha with IC50 values of (27.4+-1.8) muM and (31.7+-2.5) muM, respectively.	Resveratrol	89-100	peroxisome proliferator activated receptor alpha	Homo sapiens	204-213	
24796862-9	2014	We propose that resveratrol acts as a PPAR antagonist through its direct interaction with PPARgamma and PPARalpha.	Resveratrol	16-27	peroxisome proliferator activated receptor alpha	Homo sapiens	38-42	
24796862-9	2014	We propose that resveratrol acts as a PPAR antagonist through its direct interaction with PPARgamma and PPARalpha.	Resveratrol	16-27	peroxisome proliferator activated receptor alpha	Homo sapiens	104-113