Pub. Date : 2011 Nov 1
PMID : 21854768
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2. | Acrolein | BCL2 apoptosis regulator | Homo sapiens |
| 2 | We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL. | Acrolein | BCL2 apoptosis regulator | Homo sapiens |
| 3 | We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL. | Acrolein | BCL2 apoptosis regulator | Homo sapiens |
| 4 | Taken together, our results demonstrated that acrolein enhances TRAIL-induced apoptosis in Caki cells through down-regulation of Bcl-2 and ROS dependent up-regulation of DR5. | Acrolein | BCL2 apoptosis regulator | Homo sapiens |