PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	Acrolein	0-8	BCL2 apoptosis regulator	Homo sapiens	157-162	
21854768-6	2011	We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL.	Acrolein	14-22	BCL2 apoptosis regulator	Homo sapiens	59-64	
21854768-6	2011	We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL.	Acrolein	14-22	BCL2 apoptosis regulator	Homo sapiens	69-74	
21854768-9	2011	Taken together, our results demonstrated that acrolein enhances TRAIL-induced apoptosis in Caki cells through down-regulation of Bcl-2 and ROS dependent up-regulation of DR5.	Acrolein	46-54	BCL2 apoptosis regulator	Homo sapiens	129-134