Pub. Date : 2011 Jul
PMID : 21605904
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the link between histamine-mediated signaling and activation of inflammatory genes such as cyclooxygenase 2 (COX-2) is still unknown. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | However, the link between histamine-mediated signaling and activation of inflammatory genes such as cyclooxygenase 2 (COX-2) is still unknown. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Following stimulation with 10 muM of histamine, both store-operated Ca(2+) entry (SOCE) and COX-2 gene expression were evoked. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Histamine-mediated COX-2 activation can be prevented by 2-APB and SKF-96365, SOC channel inhibitors. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | In addition, deletion analysis of the COX-2 promoter suggested that the region between -80 bp and -250 bp, which contains NFkappaB binding sites, is the key element for histamine-mediated signaling. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Knocking down ORAI1, one of the essential molecules of store-operated calcium channels, attenuated histamine-mediated COX-2 expression and NFkappaB activation. | Histamine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |