PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21605904-3	2011	However, the link between histamine-mediated signaling and activation of inflammatory genes such as cyclooxygenase 2 (COX-2) is still unknown.	Histamine	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	100-116	
21605904-3	2011	However, the link between histamine-mediated signaling and activation of inflammatory genes such as cyclooxygenase 2 (COX-2) is still unknown.	Histamine	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	118-123	
21605904-5	2011	Following stimulation with 10 muM of histamine, both store-operated Ca(2+) entry (SOCE) and COX-2 gene expression were evoked.	Histamine	37-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97	
21605904-6	2011	Histamine-mediated COX-2 activation can be prevented by 2-APB and SKF-96365, SOC channel inhibitors.	Histamine	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	19-24	
21605904-7	2011	In addition, deletion analysis of the COX-2 promoter suggested that the region between -80 bp and -250 bp, which contains NFkappaB binding sites, is the key element for histamine-mediated signaling.	Histamine	169-178	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-43	
21605904-8	2011	Knocking down ORAI1, one of the essential molecules of store-operated calcium channels, attenuated histamine-mediated COX-2 expression and NFkappaB activation.	Histamine	99-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	118-123