CPRiL

Protein Name	prostaglandin-endoperoxide synthase 2
Organism	Homo sapiens
Gene ID	5743
Gene Symbol	PTGS2
UniProt	P35354 (PGH2_HUMAN)
Relationships	Total Number of functionally related compound(s) : 2572 Total Number of Articles : 6009
Description	prostaglandin-endoperoxide synthase 2
Gene Summary	Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
synonyms	prostaglandin G/H synthase 2 PGH synthase 2 PHS II cyclooxygenase 2 cyclooxygenase 2b prostaglandin H2 synthase 2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 Click to show/hide the synonyms
Properties