Protein Name prostaglandin-endoperoxide synthase 2
Organism Homo sapiens
Gene ID 5743
Gene Symbol


UniProt P35354 (PGH2_HUMAN)
Relationships Total Number of functionally related compound(s) : 2572
Total Number of Articles : 6009

prostaglandin-endoperoxide synthase 2

Gene Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

  • prostaglandin G/H synthase 2
  • PGH synthase 2
  • PHS II
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