Title : Reward circuitry dopaminergic activation regulates food and drug craving behavior.

Pub. Date : 2011

PMID : 21492092






1 Functional Relationships(s)
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1 Individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the COMT gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. Nicotine catechol-O-methyltransferase Homo sapiens