Protein Name catechol-O-methyltransferase
Organism Homo sapiens
Gene ID 1312
Gene Symbol


UniProt P21964 (COMT_HUMAN), A0A140VJG8 (A0A140VJG8_HUMAN)
Relationships Total Number of functionally related compound(s) : 756
Total Number of Articles : 2255


Gene Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

  • catechol O-methyltransferase
  • epididymis secretory sperm binding protein Li 98n
  • testicular tissue protein Li 42
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