PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21492092-9 2011 Individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the COMT gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. Nicotine 326-334 catechol-O-methyltransferase Homo sapiens 172-176