Title : SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.

Pub. Date : 2011 Mar 3

PMID : 21368833






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 On the genetic level, FBW7 reconstitution or MCL1 depletion restores sensitivity to ABT-737, establishing MCL1 as a therapeutically relevant bypass survival mechanism that enables FBW7-deficient cells to evade apoptosis. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens