Pub. Date : 2009 Nov 30
PMID : 19833167
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 deficiency accelerates cisplatin-induced acute renal failure but not systemic injury. | Cisplatin | interleukin 6 | Mus musculus |
| 2 | In this study, we analyzed IL-6 regulation during CDDP-induced ARF in wild-type (WT) mice and determined the pathological role of IL-6 using IL-6 knockout ((-/-)) mice. | Cisplatin | interleukin 6 | Mus musculus |
| 3 | Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development. | Cisplatin | interleukin 6 | Mus musculus |
| 4 | Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development. | Cisplatin | interleukin 6 | Mus musculus |
| 5 | Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development. | Cisplatin | interleukin 6 | Mus musculus |
| 6 | Interestingly, renal dysfunction occurred soon after administration of CDDP and became more severe in IL-6(-/-) mice than that in WT mice. | Cisplatin | interleukin 6 | Mus musculus |
| 7 | Bax might contribute to the development of CDDP-induced ARF at 24h; however, high expression levels of Bcl-x(L) and Bcl-2 might overcome the proapoptosis signaling at 72 h in IL-6(-/-) mice. | Cisplatin | interleukin 6 | Mus musculus |
| 8 | These results indicated that local and systemic elevation of IL-6 contributes to the development of CDDP-induced ARF and that IL-6 produced in renal tubular cells prevents progression of ARF at the early stage. | Cisplatin | interleukin 6 | Mus musculus |
| 9 | IL-6 deficiency accelerates CDDP-induced ARF but not development of systemic injury. | Cisplatin | interleukin 6 | Mus musculus |