PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19833167-0	2009	Interleukin-6 deficiency accelerates cisplatin-induced acute renal failure but not systemic injury.	Cisplatin	37-46	interleukin 6	Mus musculus	0-13	
19833167-4	2009	In this study, we analyzed IL-6 regulation during CDDP-induced ARF in wild-type (WT) mice and determined the pathological role of IL-6 using IL-6 knockout ((-/-)) mice.	Cisplatin	50-54	interleukin 6	Mus musculus	27-31	
19833167-6	2009	Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development.	Cisplatin	175-179	interleukin 6	Mus musculus	6-10	
19833167-6	2009	Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development.	Cisplatin	175-179	interleukin 6	Mus musculus	199-203	
19833167-6	2009	Renal IL-6 expression in most proximal tubular cells and suppressor of cytokine signaling 3 (SOCS3) gene expression significantly increased in WT mice after administration of CDDP, suggesting active IL-6 signaling during CDDP-induced ARF development.	Cisplatin	221-225	interleukin 6	Mus musculus	199-203	
19833167-7	2009	Interestingly, renal dysfunction occurred soon after administration of CDDP and became more severe in IL-6(-/-) mice than that in WT mice.	Cisplatin	71-75	interleukin 6	Mus musculus	102-106	
19833167-11	2009	Bax might contribute to the development of CDDP-induced ARF at 24h; however, high expression levels of Bcl-x(L) and Bcl-2 might overcome the proapoptosis signaling at 72 h in IL-6(-/-) mice.	Cisplatin	43-47	interleukin 6	Mus musculus	175-179	
19833167-12	2009	These results indicated that local and systemic elevation of IL-6 contributes to the development of CDDP-induced ARF and that IL-6 produced in renal tubular cells prevents progression of ARF at the early stage.	Cisplatin	100-104	interleukin 6	Mus musculus	61-65	
19833167-13	2009	IL-6 deficiency accelerates CDDP-induced ARF but not development of systemic injury.	Cisplatin	28-32	interleukin 6	Mus musculus	0-4