Pub. Date : 2009 Oct
PMID : 19439761
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. | Cholesterol | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | Activation of PPARdelta markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport. | Cholesterol | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | To test the hypothesis that PPARdelta activation leads to stimulation of transintestinal cholesterol efflux (TICE), we quantified it by intestine perfusions in FVB mice treated with PPARdelta agonist GW610742. | Cholesterol | peroxisome proliferator activator receptor delta | Mus musculus |
| 4 | Interestingly, expression of Rab9 and LIMPII, encoding proteins involved in intracellular cholesterol trafficking, was increased upon PPARdelta activation. | Cholesterol | peroxisome proliferator activator receptor delta | Mus musculus |
| 5 | These data show that activation of PPARdelta stimulates fecal cholesterol excretion in mice, primarily by the two-fold increase in TICE, indicating that this pathway provides an interesting target for the development of drugs aiming at the prevention of atherosclerosis. | Cholesterol | peroxisome proliferator activator receptor delta | Mus musculus |