PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19439761-0 2009 Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. Cholesterol 95-106 peroxisome proliferator activator receptor delta Mus musculus 0-48 19439761-2 2009 Activation of PPARdelta markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport. Cholesterol 100-111 peroxisome proliferator activator receptor delta Mus musculus 14-23 19439761-4 2009 To test the hypothesis that PPARdelta activation leads to stimulation of transintestinal cholesterol efflux (TICE), we quantified it by intestine perfusions in FVB mice treated with PPARdelta agonist GW610742. Cholesterol 89-100 peroxisome proliferator activator receptor delta Mus musculus 28-37 19439761-8 2009 Interestingly, expression of Rab9 and LIMPII, encoding proteins involved in intracellular cholesterol trafficking, was increased upon PPARdelta activation. Cholesterol 90-101 peroxisome proliferator activator receptor delta Mus musculus 134-143 19439761-10 2009 These data show that activation of PPARdelta stimulates fecal cholesterol excretion in mice, primarily by the two-fold increase in TICE, indicating that this pathway provides an interesting target for the development of drugs aiming at the prevention of atherosclerosis. Cholesterol 62-73 peroxisome proliferator activator receptor delta Mus musculus 35-44