Pub. Date : 2007 Feb
PMID : 17460390
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney. | Iron | angiotensinogen | Rattus norvegicus |
| 2 | We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage. | Iron | angiotensinogen | Rattus norvegicus |
| 3 | We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage. | Iron | angiotensinogen | Rattus norvegicus |
| 4 | Staining of serial sections revealed that some, but not all, of the renal tubular cells positive for these genes contained iron deposits in the kidney of angiotensin II-infused animals. | Iron | angiotensinogen | Rattus norvegicus |
| 5 | Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan. | Iron | angiotensinogen | Rattus norvegicus |