Title : Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis.

Pub. Date : 2007 Jul 1

PMID : 17394422






3 Functional Relationships(s)
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1 In intact mitochondria, the extent and duration of SOD1 activation was inversely correlated with mitochondrial superoxide production. Superoxides superoxide dismutase 1 Rattus norvegicus
2 Activation of IMS SOD1 by exogenous H2O2 delayed CaCl2-induced loss of transmembrane potential, decreased cytochrome c release and markedly prevented superoxide-induced loss of aconitase activity in intact mitochondria respiring at state-3. Superoxides superoxide dismutase 1 Rattus norvegicus
3 These findings suggest that H2O2, superoxide and TxrR-1 regulate IMS SOD1 activity reversibly, and that the active enzyme is implicated in protecting vital mitochondrial functions. Superoxides superoxide dismutase 1 Rattus norvegicus