Pub. Date : 2006 Feb
PMID : 16243536
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 2 | In this study, we examined the ability of piceatannol to upregulate HO-1 expression in endothelial cells. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 3 | We found piceatannol at micromolar (10-50 microM) concentrations dramatically increased HO-1 protein levels in a time-dependent manner. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 4 | Piceatannol was similarly potent in the induction of HO-1 as hemin, arsenate, and 15d-PGJ2, and was more potent than some other phytochemicals including curcumin, EGCG, baicalein, and quercetin. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 5 | Piceatannol-mediated HO-1 induction was abrogated in the presence of N-acetylcysteine and glutathione, but not by other antioxidants. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 6 | Induction of HO-1 by piceatannol was further enhanced by using buthionine sulfoximine. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 7 | Treating ECs with zinc protoporphyrin, an HO-1 inhibito blocked the anti-inflammatory effect of piceatannol. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |
| 8 | In summary, this study identified piceatannol as a novel phytochemical inducer of HO-1 expression and identified the mechanisms involved in this process. | 3,3',4,5'-tetrahydroxystilbene | heme oxygenase 1 | Homo sapiens |