PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16243536-0 2006 Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 36-52 16243536-3 2006 In this study, we examined the ability of piceatannol to upregulate HO-1 expression in endothelial cells. 3,3',4,5'-tetrahydroxystilbene 42-53 heme oxygenase 1 Homo sapiens 68-72 16243536-4 2006 We found piceatannol at micromolar (10-50 microM) concentrations dramatically increased HO-1 protein levels in a time-dependent manner. 3,3',4,5'-tetrahydroxystilbene 9-20 heme oxygenase 1 Homo sapiens 88-92 16243536-5 2006 Piceatannol was similarly potent in the induction of HO-1 as hemin, arsenate, and 15d-PGJ2, and was more potent than some other phytochemicals including curcumin, EGCG, baicalein, and quercetin. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 53-57 16243536-8 2006 Piceatannol-mediated HO-1 induction was abrogated in the presence of N-acetylcysteine and glutathione, but not by other antioxidants. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 21-25 16243536-9 2006 Induction of HO-1 by piceatannol was further enhanced by using buthionine sulfoximine. 3,3',4,5'-tetrahydroxystilbene 21-32 heme oxygenase 1 Homo sapiens 13-17 16243536-13 2006 Treating ECs with zinc protoporphyrin, an HO-1 inhibito blocked the anti-inflammatory effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 96-107 heme oxygenase 1 Homo sapiens 42-46 16243536-14 2006 In summary, this study identified piceatannol as a novel phytochemical inducer of HO-1 expression and identified the mechanisms involved in this process. 3,3',4,5'-tetrahydroxystilbene 34-45 heme oxygenase 1 Homo sapiens 82-86