Title : Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib.

Pub. Date : 2005 Oct 1

PMID : 16168844






2 Functional Relationships(s)
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1 Western blot analysis demonstrated that celecoxib downregulated the expression of Ku70 protein and inhibited the kinase activity of DNA-PKcs, which are involved in the double-stranded DNA-break repair machinery. Celecoxib protein kinase, DNA-activated, catalytic subunit Homo sapiens
2 By EMSA, it was further shown that celecoxib reduced DNA-binding activity of Ku/DNA-PKcs protein complex. Celecoxib protein kinase, DNA-activated, catalytic subunit Homo sapiens