Title : Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.

Pub. Date : 2005 Sep

PMID : 16077934






5 Functional Relationships(s)
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1 Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. betulinic acid epidermal growth factor receptor Homo sapiens
2 The results showed that BA induced EGFR tyrosine phosphorylation in a time-dependent manner. betulinic acid epidermal growth factor receptor Homo sapiens
3 Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. betulinic acid epidermal growth factor receptor Homo sapiens
4 Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. betulinic acid epidermal growth factor receptor Homo sapiens
5 Collectively, we conclude that betulinic acid transiently activated the EGFR/AKT cell survival pathway and induced survivin expression, contributing to less sensitivity in human melanoma cells. betulinic acid epidermal growth factor receptor Homo sapiens