PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16077934-0 2005 Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. betulinic acid 143-157 epidermal growth factor receptor Homo sapiens 24-28 16077934-7 2005 The results showed that BA induced EGFR tyrosine phosphorylation in a time-dependent manner. betulinic acid 24-26 epidermal growth factor receptor Homo sapiens 35-39 16077934-10 2005 Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. betulinic acid 48-50 epidermal growth factor receptor Homo sapiens 16-20 16077934-10 2005 Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. betulinic acid 48-50 epidermal growth factor receptor Homo sapiens 59-63 16077934-12 2005 Collectively, we conclude that betulinic acid transiently activated the EGFR/AKT cell survival pathway and induced survivin expression, contributing to less sensitivity in human melanoma cells. betulinic acid 31-45 epidermal growth factor receptor Homo sapiens 72-76