Pub. Date : 2003 Feb 15
PMID : 12393500
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We here demonstrate molecular mechanisms whereby PS-341 mediates anti-MM activity by inducing p53 and MDM2 protein expression; inducing the phosphorylation (Ser15) of p53 protein; activating c-Jun NH(2)-terminal kinase (JNK), caspase-8, and caspase-3; and cleaving the DNA protein kinase catalytic subunit, ATM, and MDM2. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We here demonstrate molecular mechanisms whereby PS-341 mediates anti-MM activity by inducing p53 and MDM2 protein expression; inducing the phosphorylation (Ser15) of p53 protein; activating c-Jun NH(2)-terminal kinase (JNK), caspase-8, and caspase-3; and cleaving the DNA protein kinase catalytic subunit, ATM, and MDM2. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Inhibition of JNK activity abrogates PS-341-induced MM cell death. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |