PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12393500-4	2003	We here demonstrate molecular mechanisms whereby PS-341 mediates anti-MM activity by inducing p53 and MDM2 protein expression; inducing the phosphorylation (Ser15) of p53 protein; activating c-Jun NH(2)-terminal kinase (JNK), caspase-8, and caspase-3; and cleaving the DNA protein kinase catalytic subunit, ATM, and MDM2.	Bortezomib	49-55	mitogen-activated protein kinase 8	Homo sapiens	191-218	
12393500-4	2003	We here demonstrate molecular mechanisms whereby PS-341 mediates anti-MM activity by inducing p53 and MDM2 protein expression; inducing the phosphorylation (Ser15) of p53 protein; activating c-Jun NH(2)-terminal kinase (JNK), caspase-8, and caspase-3; and cleaving the DNA protein kinase catalytic subunit, ATM, and MDM2.	Bortezomib	49-55	mitogen-activated protein kinase 8	Homo sapiens	220-223	
12393500-5	2003	Inhibition of JNK activity abrogates PS-341-induced MM cell death.	Bortezomib	37-43	mitogen-activated protein kinase 8	Homo sapiens	14-17