Pub. Date : 2001 Sep
PMID : 11520127
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 2 | In this study we investigated whether L-dopa increases the transmethylation process by inducing methionine adenosyl transferase (MAT), the enzyme that produces SAM, and catechol-O-methyl transferase (COMT), the enzyme that transfers the methyl group from SAM to L-dopa and DA. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 3 | In this study we investigated whether L-dopa increases the transmethylation process by inducing methionine adenosyl transferase (MAT), the enzyme that produces SAM, and catechol-O-methyl transferase (COMT), the enzyme that transfers the methyl group from SAM to L-dopa and DA. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 4 | The highlight of the study is the fact that L-dopa induces the enzymes MAT and COMT. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 5 | Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 6 | Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |
| 7 | Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa. | Levodopa | methionine adenosyltransferase 1A | Homo sapiens |