Protein Name methionine adenosyltransferase 1A
Organism Homo sapiens
Gene ID 4143
Gene Symbol


UniProt Q00266 (METK1_HUMAN)
Relationships Total Number of functionally related compound(s) : 384
Total Number of Articles : 364

methionine adenosyltransferase 1A

Gene Summary

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

  • S-adenosylmethionine synthase isoform type-1
  • MAT 1
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