| Protein Name | methionine adenosyltransferase 1A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4143 |
| Gene Symbol | MAT1A |
| UniProt | Q00266 (METK1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
384
Total Number of Articles : 364 |
Description |
methionine adenosyltransferase 1A |
| Gene Summary |
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008] |
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