PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11520127-0	2001	L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase.	Levodopa	0-6	methionine adenosyltransferase 1A	Homo sapiens	52-83	
11520127-4	2001	In this study we investigated whether L-dopa increases the transmethylation process by inducing methionine adenosyl transferase (MAT), the enzyme that produces SAM, and catechol-O-methyl transferase (COMT), the enzyme that transfers the methyl group from SAM to L-dopa and DA.	Levodopa	38-44	methionine adenosyltransferase 1A	Homo sapiens	96-127	
11520127-4	2001	In this study we investigated whether L-dopa increases the transmethylation process by inducing methionine adenosyl transferase (MAT), the enzyme that produces SAM, and catechol-O-methyl transferase (COMT), the enzyme that transfers the methyl group from SAM to L-dopa and DA.	Levodopa	38-44	methionine adenosyltransferase 1A	Homo sapiens	129-132	
11520127-16	2001	The highlight of the study is the fact that L-dopa induces the enzymes MAT and COMT.	Levodopa	44-50	methionine adenosyltransferase 1A	Homo sapiens	71-74	
11520127-18	2001	Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa.	Levodopa	31-37	methionine adenosyltransferase 1A	Homo sapiens	55-58	
11520127-18	2001	Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa.	Levodopa	141-147	methionine adenosyltransferase 1A	Homo sapiens	55-58	
11520127-18	2001	Thus, during PD treatment with L-dopa the induction of MAT and COMT is likely to occur and in turn increase the methylation and reduction of L-dopa and DA that may help cause the tolerance or the wearing-off effect developed to L-dopa.	Levodopa	141-147	methionine adenosyltransferase 1A	Homo sapiens	55-58