Sirolimus

ribosomal protein S6 kinase B1 ; Rattus norvegicus







99 Article(s)
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51 16326012 Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression. 2006 Feb 1
52 16391472 Atrophic remodeling of the transplanted rat heart. 2006 1
53 17065572 Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells. 2006 Dec 1
54 15358595 EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway. 2005 Feb 1
55 15604215 Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. 2005 Mar 2
56 15769867 Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms. 2005 Jun 2
57 16043946 Rapamycin ameliorates experimental autoimmune myocarditis. 2005 May 1
58 14610086 Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. 2004 Feb 27 1
59 14660591 Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. 2004 Mar 5 1
60 14990989 Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. 2004 Apr 22 1
61 15135246 Stimulation of Na-dependent phosphate transport by platelet-derived growth factor in rat aortic smooth muscle cells. 2004 May 1
62 15249188 Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning. 2004 Aug 1 2
63 12652658 Beta-adrenergic receptor-mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a phosphatidylinositol 3-kinase dependent pathway refractory to the antiproliferative action of cyclic AMP. 2003 May 1
64 11882580 Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells. 2002 Feb 1
65 11991199 Potentiation of mitogenic activity of platelet-derived growth factor by physiological concentrations of insulin via the MAP kinase cascade in rat A10 vascular smooth muscle cells. 2002 Apr-Jun 1
66 11553517 Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. 2001 Oct 1
67 10749698 Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps. 2000 Apr 1
68 10786668 U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways. 2000 Apr 15 1
69 10889198 Cell swelling-induced translocation of rat liver Na(+)/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. 2000 Sep 22 2
70 11015466 Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. 2000 Oct 1
71 11101202 Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats. 2000 Oct 1
72 11216652 Involvement of phosphoinositide-3-kinase and p70 S6 kinase in regulation of proliferation of rat lactotrophs in culture. 2000 Dec 1
73 9886844 Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells. 1999 Jan 1
74 10025577 Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells. 1999 Jan 15 1
75 10199867 Bradykinin-stimulated protein synthesis by myocytes is dependent on the MAP kinase pathway and p70(S6K). 1999 Apr 1
76 10214966 Structural requirement of leucine for activation of p70 S6 kinase. 1999 Mar 26 1
77 10216124 Inhibition of rat hepatocyte proliferation by transforming growth factor beta and glucagon is associated with inhibition of ERK2 and p70 S6 kinase. 1999 May 1
78 10579338 Insulin-like growth factor signaling pathways in rat hepatic stellate cells: importance for deoxyribonucleic acid synthesis and hepatocyte growth factor production. 1999 Dec 1
79 9458729 Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. 1998 Jan 1
80 9546621 Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes. 1998 Jan 4
81 9614103 Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. 1998 Jun 12 2
82 9712868 Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways. 1998 Aug 28 1
83 9799659 Activation of p70(S6) kinase by beta-adrenoceptor agonists on adult cardiomyocytes. 1998 Oct 1
84 9139803 Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes. 1997 May 1
85 9224649 Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase. 1997 Jul 1 1
86 9252447 p70s6k is activated by CCK in rat pancreatic acini. 1997 Jul 1
87 9299480 p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase. 1997 Sep 8 1
88 8603701 Activation of p70 S6 protein kinase is necessary for angiotensin II-induced hypertrophy in neonatal rat cardiac myocytes. 1996 Feb 5 1
89 8617780 Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways. 1996 Mar 1 1
90 8621477 Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors. 1996 Apr 12 1
91 8687386 Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells. 1996 Jun 1 2
92 8752914 p70 S6 kinase sensitivity to rapamycin is eliminated by amino acid substitution of Thr229. 1996 Jul 15 3
93 8940115 cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells. 1996 Dec 6 1
94 7487901 Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. 1995 Oct 15 1
95 7586215 Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. 1995 Dec 2
96 7638171 cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. 1995 Aug 1 2
97 7654170 Inhibitors of signalling identify differential control processes responsible for selective effects of insulin on the expression of phosphoenolpyruvate carboxykinase and gene 33 in rat H4 hepatoma cells. 1995 Sep 1 1
98 7836465 Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. 1995 Feb 3 1
99 8063749 Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes. 1994 Aug 19 1