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32890999 | Synthesis and biological evaluation of 2'-Aminochalcone: A multi-target approach to find drug candidates to treat Alzheimer's disease. | 2020 Oct |
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33007563 | Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. | 2020 Nov 15 |
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30648708 | The role of methylation in the copper(ii) coordination properties of a His-containing decapeptide. | 2019 Feb 7 |
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31491074 | Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease. | 2019 Oct 16 |
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28040476 | Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na. | 2017 Mar 15 |
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28359674 | Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors. | 2017 Oct 1 |
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| 8 |
28370344 | Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor. | 2017 Jun 5 |
1 |
| 9 |
28710924 | Identification of new BACE1 inhibitors using Pharmacophore and Molecular dynamics simulations approach. | 2017 Sep |
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| 10 |
27111489 | Determination of the protonation state for the catalytic dyad in β-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study. | 2016 May |
1 |
| 11 |
27474865 | Modeling the protonation states of β-secretase binding pocket by molecular dynamics simulations and docking studies. | 2016 Jul |
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| 12 |
27816517 | Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors. | 2016 Dec 1 |
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| 13 |
26085383 | Copper(ii) complexes of macrocyclic and open-chain pseudopeptidic ligands: synthesis, characterization and interaction with dicarboxylates. | 2015 Jul 28 |
1 |
| 14 |
25345508 | Fetzima (levomilnacipran), a drug for major depressive disorder as a dual inhibitor for human serotonin transporters and beta-site amyloid precursor protein cleaving enzyme-1. | 2014 |
2 |
| 15 |
23465612 | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | 2013 Apr 1 |
1 |
| 16 |
23640428 | Effect of pH and ligand charge state on BACE-1 fragment docking performance. | 2013 May |
1 |
| 17 |
21647837 | Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors. | 2012 |
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| 18 |
22545704 | Protonation states of the catalytic dyad of β-secretase (BACE1) in the presence of chemically diverse inhibitors: a molecular docking study. | 2012 May 25 |
2 |
| 19 |
21183353 | Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors. | 2011 Jan 1 |
1 |
| 20 |
21500352 | Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. | 2011 May |
1 |
| 21 |
20043700 | Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors. | 2010 Feb 11 |
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| 22 |
20097169 | Evidence for dimeric BACE-mediated APP processing. | 2010 Feb 26 |
3 |
| 23 |
20620068 | Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease. | 2010 Aug 1 |
1 |
| 24 |
20806954 | Structural and thermodynamic characteristics of the exosite binding pocket on the human BACE1: a molecular modeling approach. | 2010 Sep 23 |
2 |
| 25 |
19284778 | Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. | 2009 Jun 2 |
1 |
| 26 |
19547991 | Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. | 2009 Oct |
1 |
| 27 |
19854048 | Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. | 2009 Dec 1 |
1 |
| 28 |
18378702 | Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. | 2008 Jun |
2 |
| 29 |
18811140 | Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. | 2008 Oct 23 |
1 |
| 30 |
18979630 | Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases. | 2008 Aug |
1 |
| 31 |
19013073 | Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors. | 2008 Dec 15 |
1 |
| 32 |
17112725 | Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites. | 2007 Feb 15 |
1 |
| 33 |
17685503 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. | 2007 Sep 6 |
3 |
| 34 |
16451048 | Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. | 2006 Feb 9 |
1 |
| 35 |
15809332 | Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase. | 2005 Mar |
1 |
| 36 |
15456259 | Modeling the protonation states of the catalytic aspartates in beta-secretase. | 2004 Oct 7 |
3 |
| 37 |
15522224 | The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing. | 2004 Dec 3 |
1 |
| 38 |
12458195 | Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism. | 2003 Feb 14 |
1 |
| 39 |
14692784 | Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. | 2003 Dec 31 |
1 |
| 40 |
11922623 | Prediction of the tertiary structure of the beta-secretase zymogen. | 2002 Apr 5 |
1 |
| 41 |
11716984 | The functional gamma-secretase inhibitor prevents production of amyloid beta 1-34 in human and murine cell lines. | 2001 Nov 27 |
1 |
| 42 |
10677483 | Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. | 2000 Feb 15 |
1 |