Title : Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors.

Pub. Date : 2008 Dec 15

PMID : 19013073






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compound 33d, which displayed the highest BACE 1 activity (18.33+/-2.80 micromol/L) among these two series, was chosen to study the protein binding pattern and the result showed that it was in close contact with two essential catalytic aspartates (Asp32 and Asp228) of the BACE 1. Aspartic Acid beta-secretase 1 Homo sapiens