Title : Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Pub. Date : 2008 Oct 23

PMID : 18811140






1 Functional Relationships(s)
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1 An X-ray cocrystal structure with BACE-1 revealed a novel mode of binding whereby the inhibitor interacts with the catalytic aspartates via bridging water molecules. Aspartic Acid beta-secretase 1 Homo sapiens