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33429982 | Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. | 2021 Jan 8 |
1 |
| 2 |
31746435 | The cyclin‑dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma. | 2020 Jan |
1 |
| 3 |
31260568 | Inhibition of cyclin-dependent kinase activity exacerbates H2 O2 -induced DNA damage in Kindler syndrome keratinocytes. | 2019 Sep |
1 |
| 4 |
25947085 | The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. | 2015 Jun |
2 |
| 5 |
26207228 | Roscovitine in cancer and other diseases. | 2015 Jun |
3 |
| 6 |
26556339 | Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis. | 2015 Nov 4 |
2 |
| 7 |
24166139 | Prometaphase arrest-dependent phosphorylation of Bcl-2 and Bim reduces the association of Bcl-2 with Bak or Bim, provoking Bak activation and mitochondrial apoptosis in nocodazole-treated Jurkat T cells. | 2014 Jan |
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| 8 |
24327015 | An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. | 2014 Jan 21 |
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| 9 |
24337984 | The contribution of Cdc2 in rotenone-induced G2/M arrest and caspase-3-dependent apoptosis. | 2014 May |
1 |
| 10 |
23399722 | Synthesis and biological evaluation of guanidino analogues of roscovitine. | 2013 Apr |
1 |
| 11 |
22580043 | Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. | 2012 Aug |
1 |
| 12 |
23185265 | Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. | 2012 |
1 |
| 13 |
21059642 | Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3. | 2011 Jan 7 |
1 |
| 14 |
21195118 | Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. | 2011 Oct |
1 |
| 15 |
21209116 | Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. | 2011 Mar |
2 |
| 16 |
21255143 | Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. | 2011 May |
1 |
| 17 |
21565170 | Phosphorylation of human DNMT1: implication of cyclin-dependent kinases. | 2011 Jun 3 |
1 |
| 18 |
21918689 | Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. | 2011 |
1 |
| 19 |
22019170 | Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer. | 2011 Dec |
2 |
| 20 |
20163670 | Phosphorylation of inositol 1,4,5-triphosphate receptor 1 during in vitro maturation of porcine oocytes. | 2010 Feb |
1 |
| 21 |
20463006 | MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. | 2010 Aug |
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| 22 |
19230027 | R-roscovitine sensitizes anaplastic thyroid carcinoma cells to TRAIL-induced apoptosis via regulation of IKK/NF-kappaB pathway. | 2009 Jun 1 |
1 |
| 23 |
17942543 | Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome. | 2008 Jan |
2 |
| 24 |
18281518 | CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. | 2008 Feb |
1 |
| 25 |
18457570 | Effect of roscovitine, a selective cyclin B-dependent kinase 1 inhibitor, on assembly of the nucleolus in mitosis. | 2008 Apr |
3 |
| 26 |
18501396 | Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent. | 2008 Aug 15 |
2 |
| 27 |
19066455 | You never know: Cdk inhibitors as anti-cancer drugs. | 2008 Dec 15 |
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| 28 |
17125805 | Roscovitine differentially affects CaV2 and Kv channels by binding to the open state. | 2007 Mar |
2 |
| 29 |
17179992 | A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. | 2007 Jan 15 |
3 |
| 30 |
18025303 | Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. | 2007 Nov 19 |
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| 31 |
16054783 | In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase. | 2006 May |
1 |
| 32 |
16371510 | Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. | 2006 Mar |
1 |
| 33 |
16407259 | Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. | 2006 Mar 17 |
1 |
| 34 |
16969115 | Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins. | 2006 Sep |
1 |
| 35 |
17013563 | Unscheduled CDK1 activity in G1 phase of the cell cycle triggers apoptosis in X-irradiated lymphocytic leukemia cells. | 2006 Nov |
3 |
| 36 |
17043241 | Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1. | 2006 Oct 24 |
1 |
| 37 |
17065226 | A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. | 2006 Dec |
1 |
| 38 |
15695611 | Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes. | 2005 Feb |
2 |
| 39 |
15701524 | The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1. | 2005 Mar 4 |
1 |
| 40 |
15888452 | Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis. | 2005 Jul 1 |
1 |
| 41 |
15951378 | Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine. | 2005 Sep |
1 |
| 42 |
15955820 | Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity. | 2005 Aug 12 |
1 |
| 43 |
16036217 | Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis. | 2005 Sep 9 |
1 |
| 44 |
14602088 | Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism. | 2004 Mar |
2 |
| 45 |
14724573 | Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. | 2004 Jan 15 |
3 |
| 46 |
14990704 | Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virus. | 2004 Mar |
4 |
| 47 |
15016823 | The human nuclear SRcyp is a cell cycle-regulated cyclophilin. | 2004 May 21 |
1 |
| 48 |
15023361 | Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication. | 2004 Mar 11 |
2 |
| 49 |
15130771 | Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. | 2004 May 15 |
1 |
| 50 |
15231455 | Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. | 2004 |
2 |