Title : CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.

Pub. Date : 2008 Feb

PMID : 18281518






1 Functional Relationships(s)
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1 CHM-1-induced cell death, activation of Cdc2 kinase activity, and elevation of MPM2 phosphoepitopes were profoundly attenuated by roscovitine, a specific cyclin-dependent kinase inhibitor. Roscovitine cyclin dependent kinase 1 Homo sapiens