Glucose

insulin 1 ; Rattus norvegicus







221 Article(s)
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51 25658116 Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. 2015 4
52 25725286 EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells. 2015 Jun 1
53 25731850 Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion. 2015 May 15 1
54 25744490 HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells. 2015 Jul 1
55 25769956 Zerumbone protects INS-1 rat pancreatic beta cells from high glucose-induced apoptosis through generation of reactive oxygen species. 2015 May 1 5
56 25774549 Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis. 2015 Jun 3
57 25917831 PRMT4 is involved in insulin secretion via the methylation of histone H3 in pancreatic β cells. 2015 Jun 2
58 25930995 Osteocalcin protects pancreatic beta cell function and survival under high glucose conditions. 2015 Jun 19 1
59 25934392 Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells. 2015 Jun 26 5
60 25999715 Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway. 2015 2
61 26152514 Phloroglucinol Protects INS-1 Pancreatic β-cells Against Glucotoxicity-Induced Apoptosis. 2015 Nov 1
62 26224100 VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells. 2015 Nov 1
63 26243883 Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells. 2015 Oct 1 1
64 26474831 Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice. 2015 Nov 3 1
65 26949503 The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells. 2015 Nov 3
66 24265448 High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. 2014 Feb 1
67 24293163 Gastric bypass surgery may improve beta cell apoptosis with ghrelin overexpression in patients with BMI ≥ 32.5 kg/m(2.). 2014 Apr 1
68 24356960 Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. 2014 Feb 7 1
69 24459093 Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress. 2014 Oct 1
70 24734256 P38 plays an important role in glucolipotoxicity-induced apoptosis in INS-1 cells. 2014 1
71 24859892 GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins. 2014 Aug 3
72 25010593 Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression. 2014 1
73 25054881 Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element. 2014 2
74 25292013 Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. 2014 Dec 1
75 25310693 Cytoskeletal dependence of insulin granule movement dynamics in INS-1 beta-cells in response to glucose. 2014 1
76 23229155 The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes. 2013 Feb 1
77 23357280 Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. 2013 Apr 1 2
78 23412604 Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. 2013 May 1
79 23426361 Metabolome response to glucose in the β-cell line INS-1 832/13. 2013 Apr 12 1
80 23562377 Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins. 2013 Jul 15 1
81 23747317 Fibrin improves beta (INS-1) cell function, proliferation and survival through integrin αvβ3. 2013 Sep 1
82 23818898 The ETS-Domain Transcription Factor Elk-1 Regulates COX-2 Gene Expression and Inhibits Glucose-Stimulated Insulin Secretion in the Pancreatic β -Cell Line INS-1. 2013 1
83 23846350 D-glucose‑ and 3-O-methyl-D-glucose-induced upregulation of selected genes in rat hepatocytes and INS1E cells: re‑evaluation of the possible role of hexose phosphorylation. 2013 Sep 1
84 23956156 Chronic high glucose induced INS-1β cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC. 2013 Oct 1
85 24008651 Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis. 2013 1
86 24250814 The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion. 2013 1
87 22085924 Culturing INS-1 cells on CDPGYIGSR-, RGD- and fibronectin surfaces improves insulin secretion and cell proliferation. 2012 Feb 1
88 22147008 Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A. 2012 Feb 1
89 22240811 PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. 2012 Feb 2
90 22332921 Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors. 2012 May 1
91 22387546 Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE). 2012 Mar 23 1
92 22550067 Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. 2012 Jul 1 1
93 22566534 Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. 2012 Jul 1
94 22579214 Increase of INS-1 cell apoptosis under glucose fluctuation and the involvement of FOXO-SIRT pathway. 2012 Oct 2
95 22940552 MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion. 2012 Sep 21 1
96 23026370 A compound (DW1182v) protecting high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells preserves islet integrity and improves hyperglycemia in obese db/db mouse. 2012 Dec 5 2
97 21161439 Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. 2011 Apr 1
98 21163946 Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. 2011 Feb 25 1
99 21167120 Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. 2011 Apr 15 1
100 21208194 Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines. 2011 Apr 1 1