Title : The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells.

Pub. Date : 2015 Nov

PMID : 26949503






3 Functional Relationships(s)
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1 MATERIALS AND METHODS: Different concentrations of glucose were used to examine their effects on INS-1 rat beta cells in vitro. Glucose insulin 1 Rattus norvegicus
2 Knockdown of Noggin further increased apoptosis and reduced insulin secretion when INS-1 cells were exposed to high glucose. Glucose insulin 1 Rattus norvegicus
3 Finally, treatment with inhibitor of Smad phosphorylation exerted similar effects on cell apoptosis and insulin production to Noggin administration in glucose-treated INS-1 cells. Glucose insulin 1 Rattus norvegicus