N-Methyl-3,4-methylenedioxyamphetamine

solute carrier family 6 member 4 ; Rattus norvegicus







55 Article(s)
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1 32875347 The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats. 2020 Dec 1
2 30665313 A genetic deletion of the serotonin transporter differentially influences the behavioural effects of MDMA. 2019 Mar 3
3 30826457 Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats. 2019 Apr 6
4 26610922 Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity. 2016 Jan 5
5 26612383 Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study. 2016 Jan 5
6 23711978 A genetic deletion of the serotonin transporter greatly enhances the reinforcing properties of MDMA in rats. 2014 May 1
7 23949956 3,4-methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems, but not to neurotoxicity. 2014 Feb 1
8 24211539 An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. 2014 Mar 1
9 24236988 Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats. 2014 Mar 2
10 24287719 Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. 2014 May 1
11 24595820 Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats. 2014 Jun 4
12 24752593 Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats. 2014 Jul 5
13 23054066 Parallel changes in serotonin levels in brain and blood following acute administration of MDMA. 2013 Jan 2
14 23318273 Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake. 2013 Feb 7
15 22079770 Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. 2012 Jan 15 3
16 21074589 Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity. 2011 Jan 1
17 21633976 Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugs. 2011 Dec 1
18 21763331 Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. 2011 Dec 1
19 19682588 Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET. 2010 Jan 15 2
20 20002520 Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. 2010 Feb 5
21 20169574 Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. 2010 Jun 7
22 20298763 MDMA causes a redistribution of serotonin transporter from the cell surface to the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation. 2010 Jun 16 2
23 19555677 Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain. 2009 Aug 25 3
24 19616536 MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats. 2009 Sep 15 1
25 19824774 MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. 2009 Oct 2
26 19897077 Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications. 2009 1
27 18515011 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. 2008 Jul 31 1
28 18638459 MDMA treatment 6 months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibition. 2008 Sep 22 1
29 16220332 MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. 2007 Jan 4
30 17181558 In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. 2007 Feb 1
31 17359360 Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord. 2007 Apr 1
32 17629409 Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan. 2007 Aug 10 6
33 17692920 Repeated intermittent MDMA binges reduce DAT density in mice and SERT density in rats in reward regions of the adolescent brain. 2007 Nov 1
34 18005064 MDMA self-administration in rats: acquisition, progressive ratio responding and serotonin transporter binding. 2007 Dec 4
35 16434566 Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist. 2006 May 2
36 16836637 Persistent cerebrovascular effects of MDMA and acute responses to the drug. 2006 Jul 2
37 16889759 Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. 2006 Sep 21 1
38 15937150 (+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane. 2005 Sep 2
39 15979209 Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. 2005 Oct 1
40 16136551 Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. 2005 Sep 2
41 14627999 Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. 2004 Apr 1
42 15266556 3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein. 2004 Sep 15 1
43 15582680 Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. 2004 Dec 1
44 12700695 Increased anxiety 3 months after brief exposure to MDMA ("Ecstasy") in rats: association with altered 5-HT transporter and receptor density. 2003 Aug 1
45 14511335 Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. 2003 Sep 3
46 11756522 Psychostimulants differentially regulate serotonin transporter expression in thalamocortical neurons. 2002 Jan 1 3
47 12105113 Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. 2002 Jun 1
48 12325046 Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity. 2002 Dec 1 3
49 12398910 MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. 2002 Oct 25 6
50 11522596 The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. 2001 Sep 1