Glutamic Acid

folylpolyglutamate synthase ; Homo sapiens







24 Article(s)
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Pub. Year
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1 32256983 Enzymes involved in folate metabolism and its implication for cancer treatment. 2020 Apr 1
2 32694622 FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. 2020 Jul 21 1
3 31008996 Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients. 2019 Oct 1
4 20350571 Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. 2010 Jul 1
5 19131550 Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. 2009 Apr 30 2
6 20025500 A monoclonal antibody for detection of folylpolyglutamate synthetase in paraffin embedded tissues. 2009 Dec 1
7 18672898 Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. 2008 Aug 26 2
8 16884772 Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line. 2007 Mar 1
9 15705579 Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy. 2005 May 13 2
10 16132101 Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. 2005 Sep 21 1
11 12494465 Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. 2003 Feb 20 1
12 12678736 Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors. 2002 May 2
13 11389096 Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance. 2001 Jun 1 1
14 10479284 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase. 1999 Sep 9 1
15 10598551 Roles of folylpoly-gamma-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview. 1999 Apr 2
16 9306433 gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias. 1997 2
17 8958187 Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy. 1996 3
18 7565626 Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. 1995 Sep 1
19 7646057 DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase. 1995 Aug 20 1
20 8217815 Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen stimulated human lymphocytes. 1993 Aug 1
21 8255099 Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines. 1993 Dec 1
22 2906805 Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates. 1988 Dec 13 1
23 3190739 Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs. 1988 Oct 15 1
24 3431589 Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase. 1987 4