Title : Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients.

Pub. Date : 2019 Oct

PMID : 31008996






1 Functional Relationships(s)
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1 Moreover, the UHPLC-MS/MS method also allowed evaluation of FPGS enzyme kinetic parameters revealing Km values for the substrates MTX and L-glutamic acid of 64 micromol/L and 2.2 mmol/L, respectively. Glutamic Acid folylpolyglutamate synthase Homo sapiens