Title : Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy.

Pub. Date : 1996

PMID : 8958187






3 Functional Relationships(s)
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1 The data indicate that substitution for Glu in an antifolate by some Glu analogs in which the gamma-COOH is either altered or replaced (e.g., gamma-tetrazole-Glu) leads to loss of both FPGS substrate activity and binding; antifolate target specificity is unchanged, while uptake is actually enhanced. Glutamic Acid folylpolyglutamate synthase Homo sapiens
2 The data indicate that substitution for Glu in an antifolate by some Glu analogs in which the gamma-COOH is either altered or replaced (e.g., gamma-tetrazole-Glu) leads to loss of both FPGS substrate activity and binding; antifolate target specificity is unchanged, while uptake is actually enhanced. Glutamic Acid folylpolyglutamate synthase Homo sapiens
3 The data indicate that substitution for Glu in an antifolate by some Glu analogs in which the gamma-COOH is either altered or replaced (e.g., gamma-tetrazole-Glu) leads to loss of both FPGS substrate activity and binding; antifolate target specificity is unchanged, while uptake is actually enhanced. Glutamic Acid folylpolyglutamate synthase Homo sapiens