vandetanib

AKT serine/threonine kinase 1 ; Homo sapiens







20 Article(s)
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1 28842826 Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway. 2018 Jan 2
2 29517106 Vandetanib has antineoplastic activity in anaplastic thyroid cancer, in vitro and in vivo. 2018 May 1
3 29787277 Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica-Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer. 2018 Jul 2 1
4 30210625 NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines. 2018 1
5 26050198 ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. 2015 Aug 28 1
6 24256343 Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array. 2014 Jan 2
7 24526731 Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer. 2014 Apr 15 1
8 23578175 Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo. 2013 Jul 1
9 23799852 Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma. 2013 Jul 9 2
10 23822199 Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array. 2013 Jul 3 2
11 21350000 Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro. 2011 Apr 1 1
12 21970874 Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin. 2011 Nov 8 1
13 20139705 ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. 2010 Apr 15 2
14 19318229 Growth inhibition by tyrosine kinase inhibitors in mesothelioma cell lines. 2009 Jun 1
15 19622715 Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. 2009 Oct 2
16 18694994 Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. 2008 Aug 15 2
17 21479415 Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model. 2008 May-Jun 1
18 17308046 Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. 2007 Feb 1
19 16995874 ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib. 2006 Dec 2
20 17145834 Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer. 2006 Dec 1 1