Title : ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.

Pub. Date : 2006 Dec

PMID : 16995874






2 Functional Relationships(s)
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Protein Name
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1 ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). vandetanib AKT serine/threonine kinase 1 Homo sapiens
2 ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. vandetanib AKT serine/threonine kinase 1 Homo sapiens