Title : ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib.

Pub. Date : 2015 Aug 28

PMID : 26050198






1 Functional Relationships(s)
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1 The data demonstrated that ZD6474 inhibited the growth of osteosarcoma cells, and promoted G1-phase cell cycle arrest and apoptosis by inhibiting the activity of EGFR tyrosine kinase, and consequently suppressing its downstream PI3k/Akt and MAPK/ERK pathway. vandetanib AKT serine/threonine kinase 1 Homo sapiens