TAE226

protein tyrosine kinase 2 ; Homo sapiens







22 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 35452915 Design, synthesis and biological evaluation of novel FAK inhibitors with better selectivity over IR than TAE226. 2022 Jul 4
2 34757216 Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase. 2021 Dec 15 3
3 32784087 Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors. 2020 Nov 1 1
4 32979460 Mechano-stimulation initiated by extracellular adhesion and cationic conductance pathways influence astrocyte activation. 2020 Nov 20 2
5 26549408 Exploring the interaction between human focal adhesion kinase and inhibitors: a molecular dynamic simulation and free energy calculations. 2016 Nov 1
6 25625667 Cytotoxic and radiosensitizing effects of FAK targeting in human glioblastoma cells in vitro. 2015 Apr 4
7 23845217 Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity. 2013 Aug 15 1
8 22705303 Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer. 2012 Jul 13 1
9 22766511 Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. 2012 Nov 5
10 21338601 Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. 2011 May 1 4
11 21454698 Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. 2011 May 13 3
12 19784551 TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis. 2010 Dec 2
13 20441998 Usage of heparan sulfate, integrins, and FAK in HPV16 infection. 2010 Jul 20 1
14 19729215 3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226. 2009 Sep 4
15 17849451 TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. 2008 Mar 5
16 18259944 TAE226 inhibits human neuroblastoma cell survival. 2008 Mar 2
17 18628478 Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. 2008 Jul 15 3
18 19020730 TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. 2008 Dec 3
19 19030106 Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. 2008 4
20 17219439 A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. 2007 Jun 3
21 17431114 Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. 2007 Apr 6
22 18006843 Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. 2007 Nov 15 5