Pub. Date : 2012 Nov
PMID : 22766511
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. | TAE226 | protein tyrosine kinase 2 | Homo sapiens |
| 2 | In order to seek therapies targeting oral squamous cell carcinoma, we developed the novel FAK Tyr(397) inhibitor TAE226 and investigated its anti-tumor effects and mechanisms. | TAE226 | protein tyrosine kinase 2 | Homo sapiens |
| 3 | In addition, TAE226 inhibited the expression of phospho-FAK Tyr(397) and phospho AKT Ser(473), resulting in caspase-mediated apoptosis. | TAE226 | protein tyrosine kinase 2 | Homo sapiens |
| 4 | CONCLUSIONS: Our results provide compelling evidence that FAK is critically involved in oral squamous cell carcinoma and that the FAK inhibitor TAE226 can potentially be effectively used for the treatment of oral squamous cell carcinoma. | TAE226 | protein tyrosine kinase 2 | Homo sapiens |
| 5 | CONCLUSIONS: Our results provide compelling evidence that FAK is critically involved in oral squamous cell carcinoma and that the FAK inhibitor TAE226 can potentially be effectively used for the treatment of oral squamous cell carcinoma. | TAE226 | protein tyrosine kinase 2 | Homo sapiens |