Tyrosine

interferon alpha 1 ; Homo sapiens







150 Article(s)
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Pub. Year
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1 31633442 Mechanisms of Innate Immune Activation by a Hybrid Alphavirus-Rhabdovirus Vaccine Platform. 2020 Feb 1
2 32420725 IL-1β Enhances the Antiviral Effect of IFN-α on HCV Replication by Negatively Modulating ERK2 Activation. 2020 Jul 10 2
3 29886262 Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling. 2018 Jun - Jul 1
4 28498306 A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection. 2017 May 12 2
5 26481041 Growth inhibitory effect of an injectable hyaluronic acid-tyramine hydrogels incorporating human natural interferon-α and sorafenib on renal cell carcinoma cells. 2016 Jan 4
6 27802159 Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response. 2016 Nov 15 1
7 25247291 C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1). 2015 Feb 5 1
8 24131713 Rotavirus NSP1 protein inhibits interferon-mediated STAT1 activation. 2014 Jan 1
9 23072726 Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations. 2013 Jul 1
10 23910645 Protein phosphatase 2A impairs IFNα-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation. 2013 Sep 1
11 21968657 Enhanced phosphorylation of STAT-1 is dependent on double-stranded RNA-dependent protein kinase signaling in HLA-B27-expressing U937 monocytic cells. 2012 Mar 2
12 22036215 Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis. 2012 Feb 15 1
13 22191466 Interferon-alpha therapy in patients with hepatitis C virus infection increases plasma phenylalanine and the phenylalanine to tyrosine ratio. 2012 May 1
14 22312113 Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. 2012 Feb 13 1
15 20937272 Activation of STAT1 is required for interferon-alpha-mediated cell death. 2011 Jan 1 1
16 21129804 A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients. 2011 Apr 1
17 21593149 Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation. 2011 Aug 3
18 21865166 Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor. 2011 Oct 14 4
19 19014879 Interferon alpha increases metalloproteinase-13 gene expression through a polyomavirus enhancer activator 3-dependent pathway in hepatic stellate cells. 2009 Jan 2
20 19085955 Hepatitis delta virus inhibits alpha interferon signaling. 2009 Feb 1
21 19254804 Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2. 2009 Apr 25 1
22 19345260 Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. 2009 Jul 1 1
23 19396596 Bortezomib pre-treatment prolongs interferon-alpha-induced STAT1 phosphorylation in melanoma cells. 2009 Dec 1
24 19515782 Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism. 2009 Aug 2
25 18287094 Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells. 2008 Apr 18 2
26 18306331 Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon-induced antiviral protein in human hepatocyte cells. 2008 Mar 1
27 18474601 Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. 2008 Jul 4 1
28 18725457 Identification of a nuclear localization signal in suppressor of cytokine signaling 1. 2008 Dec 1
29 17095088 Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain. 2007 Mar 1
30 17290288 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. 2007 Mar 2
31 17442890 A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis. 2007 Jul 2
32 17785551 Melanoma cells exhibit variable signal transducer and activator of transcription 1 phosphorylation and a reduced response to IFN-alpha compared with immune effector cells. 2007 Sep 1 1
33 17785772 Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. 2007 Sep 15 1
34 17880940 Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. 2007 Nov 15 1
35 16595158 Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway. 2006 Aug 1
36 16731929 Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. 2006 Jun 1
37 16987558 Hyper-activated IRF-1 and STAT1 contribute to enhanced interferon stimulated gene (ISG) expression by interferon alpha and gamma co-treatment in human hepatoma cells. 2006 Aug-Sep 1
38 15611255 JAK-mediated signaling inhibits Fas ligand-induced apoptosis independent of de novo protein synthesis. 2005 Jan 1 1
39 15659558 Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. 2005 Jun 1
40 15720527 Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C: possible involvement in resistance to interferon therapy. 2005 Mar 1
41 15767445 Mumps virus V protein antagonizes interferon without the complete degradation of STAT1. 2005 Apr 1
42 15795279 Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells. 2005 Apr 1
43 15845643 Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. 2005 Jul 1
44 15944325 Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. 2005 Jun 15 2
45 16000854 Genomic DNA affinity chromatography: a technique to isolate interferon-inducible DNA binding factors. 2005 1
46 16059651 Lack of STAT 1 phosphorylation at TYR 701 by IFNgamma correlates with disease outcome in melanoma patients. 2005 1
47 16324217 Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. 2005 Dec 2 4
48 14647450 A role for Janus kinases in crosstalk between ErbB3 and the interferon-alpha signaling complex in myeloma cells. 2004 Feb 12 1
49 14690454 Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C. 2004 Apr 1 1
50 14722125 Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation. 2004 Mar 26 2