Title : On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.

Pub. Date : 2013 Dec 15

PMID : 24270847






2 Functional Relationships(s)
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1 Using Brownian dynamics simulations, we show that the preferential binding of the MDM2 protein to the geometrical isomers of Nutlin-3, an effective anticancer lead that works by inhibiting the interaction between the proteins p53 and MDM2, can be explained by kinetic arguments related to the formation of the MDM2:Nutlin-3 encounter complex. nutlin 3 tumor protein p53 Homo sapiens
2 Using Brownian dynamics simulations, we show that the preferential binding of the MDM2 protein to the geometrical isomers of Nutlin-3, an effective anticancer lead that works by inhibiting the interaction between the proteins p53 and MDM2, can be explained by kinetic arguments related to the formation of the MDM2:Nutlin-3 encounter complex. nutlin 3 tumor protein p53 Homo sapiens