Pub. Date : 2013 Dec 15
PMID : 24270847
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Using Brownian dynamics simulations, we show that the preferential binding of the MDM2 protein to the geometrical isomers of Nutlin-3, an effective anticancer lead that works by inhibiting the interaction between the proteins p53 and MDM2, can be explained by kinetic arguments related to the formation of the MDM2:Nutlin-3 encounter complex. | nutlin 3 | tumor protein p53 | Homo sapiens |
2 | Using Brownian dynamics simulations, we show that the preferential binding of the MDM2 protein to the geometrical isomers of Nutlin-3, an effective anticancer lead that works by inhibiting the interaction between the proteins p53 and MDM2, can be explained by kinetic arguments related to the formation of the MDM2:Nutlin-3 encounter complex. | nutlin 3 | tumor protein p53 | Homo sapiens |