Wortmannin

tumor protein p53 ; Homo sapiens







44 Article(s)
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1 32373892 Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity. 2020 Jun 24 2
2 31502598 Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. 2019 Oct 21 1
3 25876968 [Inhibitors of DNA-dependent protein kinase promote p53-independent apoptosis induced by 1, 4-benzoquinone in HL60 cells]. 2015 Jan 1
4 25482947 mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. 2014 1
5 23050037 Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts. 2012 2
6 20060030 Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells. 2010 Mar 1
7 20226587 Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation. 2010 Aug 1 1
8 17981542 Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. 2008 Jan 1 1
9 18289623 Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling. 2008 May 15 1
10 18332866 hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. 2008 Jul 3 1
11 18406507 MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. 2008 May 21 2
12 19062713 [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]. 2008 Jul 2
13 21783897 Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells. 2008 Jul 4
14 16990847 Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53. 2007 Mar 1
15 17135248 Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. 2007 Jan 26 2
16 17292432 Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway. 2007 Apr 1 1
17 17534123 Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. 2007 1
18 16152627 Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. 2006 Feb 15 1
19 16180010 Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide. 2006 Mar 1
20 16510557 Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. 2006 May 1
21 16527552 Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells. 2006 May 1
22 16880619 The course of uncarinic acid E-induced apoptosis of HepG2 cells from damage to DNA and p53 activation to mitochondrial release of cytochrome c. 2006 Aug 1
23 15533933 Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. 2005 Jan 14 1
24 15837074 Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. 2005 Apr 1
25 16024610 Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. 2005 Jul 15 1
26 14525955 Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase. 2004 Jan 1
27 14991746 Relationship between the radiosensitizing effect of wortmannin, DNA double-strand break rejoining, and p21WAF1 induction in human normal and tumor-derived cells. 2004 Mar 2
28 15492467 Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation. 2004 Oct 1
29 12676607 Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers. 2003 Apr 1
30 14513366 Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents. 2003 Dec 3
31 11857452 Effects of hyperthermia on p53 protein expression and activity. 2002 Mar 1
32 11864976 The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. 2002 May 10 1
33 12066222 Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway. 2002 Jul-Aug 2
34 12151394 ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. 2002 Oct 11 1
35 11160753 EBNA-LP associates with cellular proteins including DNA-PK and HA95. 2001 Mar 1
36 11302731 Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells. 2001 Apr 20 1
37 10771089 Phosphatidylinositol 3-kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after gamma-irradiation by stabilization of the protein. 2000 Apr 17 1
38 11006407 Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway. 2000 Sep 20 1
39 11090962 Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation. 2000 Dec 20 7
40 11103796 Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. 2000 Nov 15 2
41 10408175 Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. 1999 Mar 1
42 10544021 Activation of p53 in MDM2-overexpressing cells through phosphorylation. 1999 Nov 2 2
43 10576651 Effects of the protein kinase inhibitors wortmannin and KN62 on cellular radiosensitivity and radiation-activated S phase and G1/S checkpoints in normal human fibroblasts. 1999 Nov 2
44 8542574 The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. 1996 Jan 15 4