Pub. Date : 2008 Jul
PMID : 21783897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells. | Wortmannin | tumor protein p53 | Homo sapiens |
| 2 | Treatment with wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K)-related kinases, suppressed ZnSO(4)-induced phosphorylation and accumulation of p53 protein. | Wortmannin | tumor protein p53 | Homo sapiens |
| 3 | Expression of cyclin-dependent kinase inhibitor p21, one of the genes regulated by p53, was up-regulated following exposure to ZnSO(4), and suppressed by preincubation with wortmannin. | Wortmannin | tumor protein p53 | Homo sapiens |
| 4 | These results suggest that zinc might induce the phosphorylation of p53 at Ser15 through wortmannin-sensitive pathway(s) at least in part, and result in the transactivation of the p21 gene in this human pulmonary epithelial cell line. | Wortmannin | tumor protein p53 | Homo sapiens |