Copper

tumor protein p53 ; Homo sapiens







43 Article(s)
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1 33562817 Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. 2021 Feb 5 1
2 33875094 Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells. 2021 Oct 1 2
3 34708319 High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines. 2021 Dec 2
4 31935835 Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways. 2020 Jan 6 1
5 32733640 PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury. 2020 1
6 33036164 Identifying Differentially Expressed MicroRNAs, Target Genes, and Key Pathways Deregulated in Patients with Liver Diseases. 2020 Oct 6 1
7 33327383 Toward Cancer Diagnostics of the Tumor Suppressor p53 by Surface Enhanced Raman Spectroscopy. 2020 Dec 14 1
8 33409152 Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling. 2020 1
9 31096598 Neurotoxic Effect of Ethanolic Extract of Propolis in the Presence of Copper Ions is Mediated through Enhanced Production of ROS and Stimulation of caspase-3/7 Activity. 2019 May 15 1
10 31652494 The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1. 2019 Oct 22 2
11 31744518 TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1. 2019 Nov 19 1
12 31998813 Novel Isatin-based activator of p53 transcriptional functions in tumor cells. 2019 Sep 1
13 30241011 Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands. 2018 Oct 5 1
14 27913286 Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism. 2017 Jan 1
15 26427013 Ternary Dinuclear Copper(II) Complexes of a Reduced Schiff Base Ligand with Diimine Coligands: DNA Binding, Cytotoxic Cell Apoptosis, and Apoptotic Mechanism. 2016 Mar 1
16 27046389 Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53. 2016 Jul-Aug 1
17 24975171 Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease. 2015 Jan 1
18 25660211 DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex. 2015 Apr 1
19 26438057 Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload. 2015 Dec 5
20 24445997 Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy. 2014 Mar 2
21 25216733 Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. 2014 Dec 1
22 23354308 Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells. 2013 May 2
23 23401182 The effect of zinc and the role of p53 in copper-induced cellular stress responses. 2013 Jul 6
24 22056254 Evaluation of copper-64-labeled somatostatin agonists and antagonist in SSTr2-transfected cell lines that are positive and negative for p53: implications for cancer therapy. 2012 Feb 5
25 20875833 Role of hepatocyte nuclear factor 4α in controlling copper-responsive transcription. 2011 Jan 3
26 20185936 Penicillamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer. 2010 1
27 17938576 The role of p53 in the trafficking of copper-64 to tumor cell nuclei. 2008 Jan 3
28 18045546 Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation. 2008 Jan 1 3
29 18791921 Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India--a high risk area. 2008 1
30 19013355 Metals and apoptosis: recent developments. 2008 1
31 21423838 Copper-Induced Cytotoxicity and Transcriptional Activation of Stress Genes in Human Liver Carcinoma (HepG(2)) Cells. 2008 1
32 17234160 Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis. 2007 May 1 1
33 17477370 P53 mediated regulation of metallothionein transcription in breast cancer cells. 2007 Dec 15 1
34 15711927 Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. 2005 Jan 6
35 15880691 Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis. 2005 Aug 15 1
36 16246896 Copper alters the conformation and transcriptional activity of the tumor suppressor protein p53 in human Hep G2 cells. 2005 Nov 5
37 16391388 Expression profiling of p53-target genes in copper-mediated neuronal apoptosis. 2005 5
38 15001399 Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. 2004 Mar 15 4
39 11964141 Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. 2002 Aug 1 3
40 12095159 Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper-induced neurotoxicity. 2002 12
41 11340094 Tumor suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells. 2001 May 5
42 11050162 Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. 2000 Nov 7 1
43 9315628 Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. 1997 Oct 5